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Pathophysiology End of term Exam BIOL122

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Pathophysiology End of term Exam BIOL122


CASE STUDY ONE (25 marks)
Mary-Lou is a 75-year-old widow, who lost her husband to cancer over a year ago. Her family and
friends have noticed that she has been very teary, has low self-esteem, and has lost interest in the
things she used to love, such as going to bingo with her friends and gardening. Her family initially
put this down to the loss of her husband and thought it would pass with time. However, they are
now getting really concerned as they have noticed that Mary-Lou’s mood is not improving
still. When asked by her daughter if she is sleeping well, she says she has been drinking wine every
night to help her go to sleep because it makes her feel happy and relaxed. What started as one glass
a night has now increased to two or three glasses a night, and she has also started drinking during
the day. Her daughter has noticed that her mum’s face always appears flushed and that she has had
quite a few colds lately. Mary-Lou is also losing her balance and experiencing mood swings. Her
daughter is worried that she is relying too heavily on alcohol and fears that she is starting to
get short-term memory loss from the alcohol consumption. She has been forgetting things such as
where she put her keys, whether she turned on the washing machine, and why she opened the
fridge. Further, Mary-Lou tends to forget the topic of conversation when talking with her daughter
on the phone and has also been getting disorientated and lost when she goes out on her daily
walks. The other day, for example, a neighbor rang her daughter to tell her that she found Mary-Lou
wandering around aimlessly, and when questioned what she was doing, Mary-Lou snapped and said
she was trying to get home. Her daughter decided it was time to take Mary-Lou to the local GP to
work out what was going on with her.
After listening to the signs and symptoms Mary-Lou was experiencing, the GP diagnosed her with
depression and prescribed a SSRI to be taken daily. Based on the results of clinical and radiological
assessments, the GP determined that she also had early onset Alzheimer’s disease. He prescribed a
cholinesterase inhibitor and gave the family information on support groups and tips on what to do
from here on in. He also prescribed a tranquiliser to be taken daily.

Pathophysiology End of term Exam BIOL122

Question 1 (5 marks)
Based on the description above
 Select/name one of the diseases/conditions Mary-Lou is suffering from and describe
two signs and/or symptoms from Mary-Lou’s history that support your selection.
 Explain the pathophysiology of the condition you named
Question 2 (3 marks)
Explain the mechanism of action of one drug type Mary-Lou is prescribed with and describe how
these drug actions help mitigate some of her symptoms. In you answer, make references to the
pathophysiology of the relevant disease and relate the chosen drug’s mechanism of action to the
aetiology/pathogenesis of the disease.

Question 3 (4 marks)
The following questions relate to a drug called MedZ:
a. MedZ contains 200 mg of the active ingredient in an intestine-solvent capsule. The active
ingredient is effectively transported across the intestinal mucosa, which ensures that 78% of
the drug is absorbed and enters the portal circulation. The drug undergoes a significant
degree of first-pass metabolism, in which process 55% of the drug passing through the liver
gets metabolized and therefore degraded to an inactive product. Calculate MedZ’s
bioavailability and show your calculations (2 marks).

b. When administered alone, 82% of MedZ is bound to plasma albumin. However, because
of the higher plasma protein binding affinity of another drug, called MedY, when MedZ and
MedY are administered together, the bound fraction of MedZ decreases to 35%.
i. Identify the type of drug interaction between MedZ and MedY in the present
scenario and give your rationale (1 mark).
ii. Assuming that MedZ and MedY are administered together in an elderly patient,
explain if the dose of MedZ should be decreased, increased, or left unchanged and
give your rationale. (1 marks).

Mary-Lou’s family was happy with the management plan established by the doctor as Mary-Lou was
progressing quite well. She was using notepads to jot down reminders, a pillbox to keep her
medication organized, and a calendar to record appointments. Her family members were helping
her with routine tasks such as cooking and paying bills. She was feeling much happier and did not
have to rely on alcohol to go to sleep. One day she was feeling so good she decided to walk to her
GP appointment alone. On her way there she stumbled over a branch and fell. She felt excruciating
pain in her hip. A passer-by called an ambulance, and she was taken to the emergency department
at the Royal Melbourne Hospital. An X-ray revealed that she had hip fracture and had to have
surgery to repair it. Mary-Lou wondered whether this was linked to the pain she had been
experiencing in her left knee for a while now. The specialist explained to Mary-Lou that the pain in
her left knee was likely due to degeneration of her cartilage and said that the fracture might have
been due to weakened bones. He told her he would like her to have a bone mineral density test to
measure her bone density. The DEXA scan gave a T-score of −3.0. Mary-Lou is now given
bisphosphonates and told to increase her daily intake of calcium.

Pathophysiology End of term Exam BIOL122

Question 4 (5 marks)
Name the disease affecting Mary-Lou’s left knee and describe two characteristic clinical
manifestations of this pathology (2 mark). Explain the aetiology and pathophysiology of the disease
(3 mark).
Question 5 (5 marks)
Considering Mary-Lou’s T-score, identify the disease she suffers from, briefly describe the
pathogenesis of this disease, describe the mechanism of action of bisphosphonate administration,
and explain the benefits of this treatment in her present condition.
Question 6 (3 marks)
Discuss why Mary-Lou’s fracture may take longer to heal than it would for someone who was half
her age. In your answer, you are expected to name and discuss three physiological factors that are
needed for healing to take place and explain how each of the factors you identified is affected by

CASE STUDY 2 (8 marks)
Hilda Wilde is a 45-year-old woman, who was diagnosed with asthma as a child. She recalls her first
asthma attack being horrendous; chest tightness, breathing difficulty, wheezing, feeling anxious, and
sweating profusely. She was rushed to hospital and spent many days in hospital as a child until she
managed to work out the triggers and control them early. The triggers for her asthma were cold
temperature, pollen, smoky environment, and respiratory infection/cold, which continue to be the
triggers throughout her adult life. She also developed hay fever and an allergy to penicillin in her
20’s, which didn’t surprise her as her mum also had these conditions.
One cold spring day, Hilda is outside gardening as she is finding herself stressed by the current
coronavirus and gardening usually relaxes her. Hilda is making good progress on weeding when she
starts to experience those dreaded sensations she knows only too well; tightness in the chest,
shortness of breath, and dizziness. She starts to wheeze and cannot stop coughing. Her husband
notices Hilda is struggling and brings Hilda’s inhaler (Ventolin) for her. However, Hilda’s wheezing
and shortness of breath does not ease off, even with her inhaler. She finds it hard to talk or get up
and walk. Her lips start to turn blue. Hilda’s husband calls an ambulance, and Hilda is taken to
hospital where she is given corticosteroids. She is told she has to stay in hospital a few days so that
her condition can be monitored. However, Hilda is worried about staying in hospital due to the novel
coronavirus outbreak. Her GP has previously told her that if she contracts the virus, she is at a
greater risk of developing more serious symptoms, such as pneumonia or acute
respiratory distress. The hospital staff have assured her that they take all the necessary precautions:
all coronavirus-affected patients are isolated in private rooms, and all healthcare staff practice
proper hand hygiene and appropriate use of PPE.
A few days later, Hilda’s asthma is under control, and she is now discharged from hospital. She is
told to take her preventer medicine every day, even when she is feeling well. She is also told to
follow routine practices and precautions to lessen her risk of contracting coronavirus.
Question 1 (2 marks)
Choose one of Hilda’s triggers and explain how it contributes to the pathophysiology of her asthma.
Question 2 (4 marks)
Hilda has been told to take her ‘preventer’ medication everyday.
a. Name the broad drug category preventer medications belong to, describe their
mechanism of action, and explain their benefits in Hilda’s case. (2 marks)
b. Describe the method and one benefit of topical administration of preventer
medications (2 marks).

Question 3 (2 marks)
Hilda has been advised to get the AstraZeneca vaccine to reduce the risk of contracting coronavirus.
She is hesitant as she has heard that the Pfizer vaccine is ‘better’. She doesn’t understand the
doctor’s explanation of the two vaccines. Using terms a patient can understand, describe one
difference and one similarity between the mechanism of action of the Pfizer and AstraZeneca COVID

CASE STUDY 3 (16 marks)
Bruce is a 47-year-old journalist, who decides he needs to visit his doctor due to some
gastrointestinal symptoms. At first it just started out as a bit of abdominal pain and cramping,
followed by diarrhea so at first Bruce just thought he had a stomach bug. But weeks went by and the
diarrhea just increased in frequency, and instead of feeling better, he started to feel really fatigued.
This had been going on for 8 months before his wife finally convinced him to make an appointment
with a doctor, who then referred him to a gastroenterologist. A couple of months later when he
finally goes to his specialist appointment, Bruce admits after questioning that he has had bleeding
with his stool, but he didn’t want to tell the doctor as he was embarrassed and didn’t want to get
checked for hemorrhoids. The gastroenterologist also asks many questions about Bruce’s diet and
his weight and discovers that Bruce has lost 15 kg in the past year despite eating a lot of hot chips
and mashed potatoes – the only thing Bruce feels doesn’t make his diarrhea worse. The
gastroenterologist then tells Bruce he would like to perform a colonoscopy to investigate further.
After the colonoscopy, the surgeon tells Bruce that they found a number of polyps in his bowel,
which is not necessarily a cause for concern as many polyps are benign, but they will have to wait on
the results of the biopsies to make sure none of them were malignant. A week later the surgeon calls
Bruce; unfortunately, it is bad news – the biopsy shows evidence that the growth is malignant and
anaplastic and that they can’t rule out metastatic growths. Bruce is called back in for follow-up tests,
and they find that there is an abnormal growth in his liver also.
Bruce is now sent to an oncologist, who recommends that he has surgery to remove any remaining
polyps, a portion of his bowel, and the abnormal growth from his liver. Based on the advice from his
oncologist, Bruce also decides to undergo chemotherapy treatment. Whilst doing some routine
checks after his treatment, Bruce is informed he has neutropenia.

Question 1 (4 marks)
Describe two similarities and two differences between hyperplasia and cancer.
Question 2 (4 marks)
On follow-up examinations, Bruce is found to have a brain tumour. Biopsy results reveal that the
cancer cells taken from his brain tumour have the morphological characteristics of colorectal cancer.
Considering brain cells are permanent cells, explain the most likely reason for this finding.
Question 3 (2 marks)
Explain why patients who have leukaemia may have excessively high numbers of white blood cells in
their blood, yet they are immunocompromised.

Bruce’s friend Greg has been trying to support him throughout his journey. Greg is a 42-year old ITspecialist, who suffers from type II diabetes mellitus, which has been under control using an oral
anti-hyperglycaemic medication and a reasonably healthy diet. Rather disturbingly, however, Greg
has been experiencing numbness and some awkward tingling in his left foot recently.
Question 4 (3 marks)
Assuming that Greg’s present symptoms are associated with his underlying disease, name the
condition responsible for his numbness and tingling, and explain the link between type II diabetes
and the condition you identified.
Question 5 (1 mark)
Greg takes an oral anti-hyperglycaemic medication. Explain why insulin administration is not
recommended in his condition.
Question 6 (2 marks)
Explain how glucose uptake of Greg’s (i) endothelial and (ii) resting skeletal muscle cells changes
when he is experiencing a hyperglycaemic episode and give your rationale.

CASE STUDY 4 (11 Marks Total)
Maria is a 67-year-old retired, obese woman, who lives with her husband Max. She enjoys sitting
down to a movie every night with a bottle of Shiraz and a large packet of salt and vinegar chips or
tub of cookies and cream ice cream. She has always loved a glass or two of wine with dinner, but
now figures she can have a few more since she no longer has to get up for work. Maria doesn’t like
to exercise, her only form of exercise is walking around Coles on Friday whilst doing her weekly
shopping. Her sister has asked her to join her walking group on numerous occasions, but Maria
would rather stay home and bake. Maria’s mother moved in with her many years ago, when her
father passed away from a heart attack at the age of 60. Her mother isn’t in the best of health, she
has type II diabetes and hypertension, which she controls with medication.
One day Maria decides to visit her neighbour, taking with her a batch of freshly baked cookies.
Whilst walking to her neighbour’s house, she notices that she is short of breath and is feeling a slight
pain in her chest, but when she sits down, she feels fine, so she dismisses it once again, putting it
down to her poor fitness. However, on her way home she begins to feel light-headed and weak, and
feels like she is going to be sick. She notices that she has been feeling like this quite a lot lately, even
when resting in the evening, so she decides to make an appointment with her GP for later in the
At the medical clinic the GP looks at Maria’s medical history. She was diagnosed with hypertension
four years ago and has tried many different medications to treat the hypertension. She was
currently taking beta blockers. The GP worries about Marias latest symptoms so writes a referral for
her to see a cardiovascular specialist for an ECG and a coronary angiogram to determine why Maria
has been short of breath and unwell.
One day, whilst waiting for her results, Maria starts to feel more nauseous and dizzier than usual.
She starts to feel clammy and sweaty, and her face seems gray in colour. The chest pain returns, but
now feels like a crushing pain, and she can’t breathe. Her husband, Max, dials 000, and she is rushed to hospital. An ECG shows that Maria has ST elevation, and a blood test indicates that she has high
levels of myocardium-specific troponin in her blood. Maria is given heparin intravenously as well as
an anti-platelet and fibrinolytic drug. She is taken into surgery, where a coronary angioplasty is performed.

Question 1 (5 marks)
Before her current problems, Maria was prescribed a beta blocker for her hypertension. Explain the
benefits of beta blocker administration in the treatment of hypertension with specific emphasis on
how this treatment reduces blood pressure
Question 2 (3 marks)
A couple of weeks before her current episode, Maria noticed that ‘she was short of breath and was
feeling a slight pain in her chest, but when she sat down for a few minutes, she felt much better and
the pain disappeared.’ Name the condition Maria was most likely experiencing and explain its
Question 3 (3 marks)
Considering her clinical symptoms and laboratory findings, name the disease Maria is suffering from
when admitted to the hospital and explain the benefits of heparin administration in her present

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